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September 2024 - January 1920

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April 2022, Vol 158, No. 4, Pages 347-458

Viewpoint

How Dermatologists Can Address the Structural and Social Determinants of Health—From Awareness to Action

Abstract Full Text
JAMA Dermatol. 2022;158(4):351-352. doi:10.1001/jamadermatol.2021.5925

This Viewpoint considers the structural and social determinants of health in dermatology and suggests ways that dermatologists can use their roles as clinicians, advocates, researchers, and educators to improve health equity.

Editorial

Why Diversity in Dermatology Clinical Trials Should No Longer Be Optional: Dismantling Structural Racism in Dermatology

Abstract Full Text
JAMA Dermatol. 2022;158(4):353-354. doi:10.1001/jamadermatol.2021.5190

Ichthyosis Scoring System—A Powerful Tool in the Era of Immune Pathway–Targeted Therapies for Ichthyosis

Abstract Full Text
JAMA Dermatol. 2022;158(4):354-356. doi:10.1001/jamadermatol.2021.5342

Understanding the Potential Promise and Pitfalls of Intravenous Gentamicin as a Therapy for Epidermolysis Bullosa

Abstract Full Text
JAMA Dermatol. 2022;158(4):356-358. doi:10.1001/jamadermatol.2021.5630
Original Investigation

Development and Initial Validation of a Novel System to Assess Ichthyosis Severity

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):359-365. doi:10.1001/jamadermatol.2021.5917

This qualitative study describes a comprehensive and user-friendly instrument to measure total body ichthyosis severity in adults and children.

Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):366-374. doi:10.1001/jamadermatol.2021.5992

This nonrandomized clinical trial of patients with junctional epidermolysis bullosa assesses whether treatment with intravenous gentamicin can safely increase laminin 332 expression.

Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):375-381. doi:10.1001/jamadermatol.2021.6019

This study examines whether there is an association between short-term exposure to air pollution and psoriasis flares.

Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis

Abstract Full Text
free access has audio
JAMA Dermatol. 2022;158(4):382-389. doi:10.1001/jamadermatol.2021.6096

This cohort study estimates the risk of stage-specific Merkel cell carcinoma recurrence and mortality over time since diagnosis.

Implications of Satellitosis or In-transit Metastasis in Cutaneous Squamous Cell Carcinoma: A Prognostic Omission in Cancer Staging Systems

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):390-394. doi:10.1001/jamadermatol.2022.0001

This multi-institutional cohort study of patients with cutaneous squamous cell carcinoma examines the association of satellitosis or in-transit metastasis with clinical outcomes to determine prognostic implications.

Trends in Debt Valuations of Private Equity–Backed Dermatology Groups Before and During the COVID-19 Pandemic

Abstract Full Text
free access has active quiz
JAMA Dermatol. 2022;158(4):395-403. doi:10.1001/jamadermatol.2022.0009

This cross-sectional study examines the valuations of dermatology private equity–backed group debt instruments in business development corporations’ portfolios both before and during the COVID-19 pandemic.

Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials

Abstract Full Text
open access
JAMA Dermatol. 2022;158(4):404-413. doi:10.1001/jamadermatol.2022.0029

This analysis of 2 randomized clinical trials evaluates long-term (52 weeks) efficacy and safety of upadacitinib treatment in patients with atopic dermatitis.

Spectrum of Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients in the US

Abstract Full Text
free access has audio
JAMA Dermatol. 2022;158(4):414-425. doi:10.1001/jamadermatol.2022.0036

This cohort study examines the spectrum of disease and risk factors for nonkeratinocyte skin cancers in solid organ transplant recipients.

Estimating Overdiagnosis of Melanoma Using Trends Among Black and White Patients in the US

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):426-431. doi:10.1001/jamadermatol.2022.0139

This cohort study used trends for mortality due to melanoma among Black patients in the US as a marker to estimate melanoma incidence among White patients in the US.

Associations of Internalized Skin Bias With Age, Adverse Psychopathology, and Health-Related Quality of Life Among Patients With Hidradenitis Suppurativa: A Cross-sectional Analysis

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):432-438. doi:10.1001/jamadermatol.2022.0248

This cross-sectional study of patients with hidradenitis suppurativa evaluates internalized skin bias to determine if it mediates the associations between adverse psychopathological outcomes and impaired health-related quality of life.

Brief Report

Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants

Abstract Full Text
JAMA Dermatol. 2022;158(4):439-443. doi:10.1001/jamadermatol.2022.0112

This case report examines the use of systemic gentamicin as a translational readthrough inducer for the treatment of epidermolysis bullosa simplex with muscular dystrophy owing to PLEC1 pathogenic nonsense variants.

Images in Dermatology

Clinically Amyopathic Juvenile Dermatomyositis

Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(4):445. doi:10.1001/jamadermatol.2021.5310

This case report describes ragged cuticles; flat-topped pink papules overlying the bilateral metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints that were consistent with Gottron papules; and a spontaneous skin ulceration on the right knee.

Lupus Pernio

Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(4):446. doi:10.1001/jamadermatol.2021.6007

This case report describes violaceous papules on the nasal alae and medial periorbital skin, hypopigmented indurated plaques on the bilateral upper extremities and back, and verrucous plaques on the lower extremities and back.

JAMA Dermatology Clinicopathological Challenge

A Case of Unilateral Focal Hyperkeratosis

Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(4):447-448. doi:10.1001/jamadermatol.2021.5931

A patient in their 50s presented with asymptomatic keratotic papules that had first appeared on the fingers and toes more than 10 years ago and then progressed proximally to areas on the left side of the body only. What is your diagnosis?

Generalized Micropapular Eruption in a Teenager

Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(4):449-450. doi:10.1001/jamadermatol.2022.0066

A teenaged boy presented with a 1-year history of asymptomatic cutaneous lesions on the face that had spread to the trunk and extremities; he also had asthenia and mild intermittent arthralgias. What is your diagnosis?

Research Letter

The ñ Sign: A Visual Clue for the Histopathologic Diagnosis of Psoriasis

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):451-452. doi:10.1001/jamadermatol.2022.0015

This qualitative study describes a visual clue for the diagnosis of psoriasis, in which the sum of the fragmentation and separation of the laminar parakeratotic stratum corneum and hyperplasia with regular elongation of the rete ridges resembles the letter ñ on histopathologic biopsy specimens.

Training and Practice Characteristics of International Medical Graduates in Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):452-454. doi:10.1001/jamadermatol.2022.0136

This cross-sectional study uses demographic data from US health care and county sources to reveal training and practice characteristics of international medical graduates (IMGs) in dermatology.

Observation

Association of Treatment With Secukinumab With Exacerbation of Dermatomyositis in a Patient With Psoriasis

Abstract Full Text
JAMA Dermatol. 2022;158(4):454-456. doi:10.1001/jamadermatol.2021.6011

This case report describes a woman in her 20s with a history of psoriasis and juvenile dermatomyositis who presented for management of worsening psoriasis at a time when her juvenile dermatomyositis had been in remission for several years.

Disseminated Herpes Infection Following Talimogene Laherparepvec Administration

Abstract Full Text
JAMA Dermatol. 2022;158(4):456-457. doi:10.1001/jamadermatol.2022.0020

This case report describes a 69-year-old woman who received treatment with ipilimumab and talimogene laherparepvec therapy following metastasis of melanoma to the left inguinal lymph nodes, skin of left lower extremity, and vulva.

Treatment of Oral Erosive Lichen Planus With Upadacitinib

Abstract Full Text
JAMA Dermatol. 2022;158(4):457-458. doi:10.1001/jamadermatol.2022.0147

This case report describes a 45-year-old woman who presented with painful oral erosions and chronic human leukocyte antigen B27–positive psoriatic peripheral arthritis with associated recurrent anterior uveitis.

JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2022;158(4):347. doi:10.1001/jamadermatol.2021.4199
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