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September 2024 - January 1920

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Issue

December 2022, Vol 158, No. 12, Pages 1351-1464

Original Investigation

Apremilast in Recalcitrant Cutaneous Dermatomyositis: A Nonrandomized Controlled Trial

Carole Bitar, MD; Thien Ninh, MD; Katherine Brag, MD; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1357-1366. doi:10.1001/jamadermatol.2022.3917

This nonrandomized controlled trial investigates the overall response rate associated with apremilast as an add-on therapy among patients with recalcitrant cutaneous dermatomyositis.

Lifetime Sunburn Trajectories and Associated Risks of Cutaneous Melanoma and Squamous Cell Carcinoma Among a Cohort of Norwegian Women

Simon Lergenmuller, PhD; Corina S. Rueegg, PhD; Flavie Perrier, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1367-1377. doi:10.1001/jamadermatol.2022.4053

This cohort study aims to identify lifetime trajectories of sunburns and compare the association between these trajectories and subsequent risk of cutaneous melanoma and squamous cell carcinoma.

Factors Associated With Dermatologic Follow-up vs Emergency Department Return in Patients With Hidradenitis Suppurativa After an Initial Emergency Department Visit

Cynthia X. Wang, MD, MPHS; Joanna L. Buss, MS; Matthew Keller, MS; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1378-1386. doi:10.1001/jamadermatol.2022.4610

This cohort study assesses the interventions and patient factors associated with emergency department return following an initial emergency department visit for hidradenitis suppurativa.

  • Podcast: Dermatologic Follow-up vs Emergency Department Return Among Patients With Hidradenitis Suppurativa

Cost-effectiveness of Response-Adapted De-escalation of Immunotherapy in Advanced Melanoma

Zachary Cartun, MD; Wolfgang G. Kunz, MD, MHBA; Lucie Heinzerling, MD, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1387-1393. doi:10.1001/jamadermatol.2022.4556

This economic evaluation aims to determine the cost-effectiveness of ipilimumab discontinuation for patients with interim imaging-confirmed tumor response in the treatment of advanced melanoma.

Association of Apremilast With Vascular Inflammation and Cardiometabolic Function in Patients With Psoriasis: The VIP-A Phase 4, Open-label, Nonrandomized Clinical Trial

Joel M. Gelfand, MD, MSCE; Daniel B. Shin, PhD; April W. Armstrong, MD, MPH; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1394-1403. doi:10.1001/jamadermatol.2022.3862

This nonrandomized clinical trial including adults with psoriasis investigates the association of apremilast with aortic vascular inflammation, cardiometabolic function, and adiposity.

Brief Report

Evaluation of Hidradenitis Suppurativa Diagnostic Criteria in Pediatric Patients

Nicole W. Kittler, MD; Jazzmin C. Williams, BS; Margaret V. Kudlinski, BS; et al.
Abstract Full Text
JAMA Dermatol. 2022;158(12):1404-1408. doi:10.1001/jamadermatol.2022.4564

This cross-sectional study examines the proportion of pediatric patients with hidradenitis suppurativa who meet existing consensus-derived diagnostic criteria.

Association of Serum Dupilumab Levels at 16 Weeks With Treatment Response and Adverse Effects in Patients With Atopic Dermatitis: A Prospective Clinical Cohort Study From the BioDay Registry

Lotte S. Spekhorst, MD; Marlies de Graaf, MD, PhD; Floris Loeff, PhD; et al.
Abstract Full Text
JAMA Dermatol. 2022;158(12):1409-1413. doi:10.1001/jamadermatol.2022.4639

This prospective clinical cohort study evaluates serum dupilumab levels at 16 weeks of treatment to assess an association with adverse effects and treatment response in 295 patients with atopic dermatitis.

Review

Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021: A Systematic Review

Sophia Ly, BA; John Miller, BA; Lauren Tong, MLIS; et al.
Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(12):1419-1428. doi:10.1001/jamadermatol.2022.3911

This systematic review assesses inclusion of patient-reported outcome measures in randomized clinical trials on acne and rosacea treatments and the use of such measures as a primary outcome.

Consensus Statement

Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement From the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative

Yael A. Leshem, MD, MCR; Joanne R. Chalmers, PhD; Christian Apfelbacher, PhD; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1429-1435. doi:10.1001/jamadermatol.2022.4211

This Consensus Statement recommends instruments to measure eczema control and itch intensity in patients with atopic eczema in clinical practice.

JAMA Dermatology Clinical Evidence Synopsis

Systemic Interventions for Treatment of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Summary of a Cochrane Review

Megan H. Noe, MD, MPH, MSCE; Robert G. Micheletti, MD
Abstract Full Text
JAMA Dermatol. 2022;158(12):1436-1437. doi:10.1001/jamadermatol.2022.4543

This clinical evidence synopsis summarizes a Cochrane review on the use of systemic immunomodulatory therapies to decrease mortality rates in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Images in Dermatology

Hunter Syndrome

Piyush Kumar, MD; Pratap C. Das, MD; Anupam Das, MD
Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(12):1438. doi:10.1001/jamadermatol.2022.4049

This case report describes multiple symmetric, skin-colored papulonodules overlying the scapulae and posterior shoulders that gave the appearance of pebbled skin.

Tinea Nigra Palmaris

Neerja Saraswat, MD, DNB; Durga Madhab Tripathy, MD, DNB; Sushil Kumar, MD
Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(12):1439. doi:10.1001/jamadermatol.2022.4442

This case report describes multiple coalescing brownish black macules with irregular borders over the left palm and palmar aspect of the digits, with black pigmentary accentuation over the creases.

JAMA Dermatology Clinicopathological Challenge

Multiple Yellowish Plaques in a Cobblestone Pattern on the Tongue

Eduardo Rozas-Muñoz, MD; Oscar Venegas-Rebolledo, DDS, OMFS; Juan-Andres Madariaga, MD
Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(12):1440-1441. doi:10.1001/jamadermatol.2022.4751

A man in his 80s presents with multiple yellowish to erythematous papules and verrucous cobblestone-like plaques on the mucosal surface on both sides of his tongue. What is your diagnosis?

Indurated Plaque With Ulceration on the Dorsum of the Left Hand

Juanjuan Li, MS; Xiaomo Wu, PhD; Borui Chen, MD, PhD
Abstract Full Text
has active quiz
JAMA Dermatol. 2022;158(12):1442-1443. doi:10.1001/jamadermatol.2022.4889

A man in his 70s presented with a 6-month history of a rash on the left forearm, which gradually increased in severity. What is your diagnosis?

JAMA Dermatology Patient Page

Sarcoidosis of the Skin

Sotonye Imadojemu, MD, MBE; Misha Rosenbach, MD
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1464. doi:10.1001/jamadermatol.2022.0360

This Patient Page describes the symptoms, diagnosis, and treatment of sarcoidosis of the skin.

Research Letter

Predicting DRESS Syndrome Recurrence鈥擳he ReDRESS Score

Ajay N. Sharma, MD, MBA; Kenneth Murphy, PhD; Samantha Shwe, BS; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1445-1447. doi:10.1001/jamadermatol.2022.3491

This cross-sectional study of DRESS syndrome cases creates a model capable of predicting recurrence to identify patients most at risk.

State Medicaid Coverage of Human Papillomavirus Vaccination in Adults and Implications for Dermatologists

Nathaniel Goldman, BA; Christy Nwankwo, BA; Alexandra P. Charrow, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1447-1449. doi:10.1001/jamadermatol.2022.3500

This cross-sectional study examines state Medicaid coverage of human papillomavirus vaccination in adults aged 27 to 45 years and discusses the implications of the results for dermatologists.

Risk Factors for Vancomycin Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Kimberly G. Blumenthal, MD, MSc; Santiago Alvarez-Arango, MD; Xiaoqing Fu, MS; et al.
Abstract Full Text
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JAMA Dermatol. 2022;158(12):1449-1453. doi:10.1001/jamadermatol.2022.3541

This case-control study uses single-institution data to explore risk factors associated with vancomycin drug reaction with eosinophilia and systemic systems (DRESS) syndrome.

Validation of Case Identification for Melasma Using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision Codes

Nicholas Theodosakis, MD, PhD; Jaewon Yoon, BA; Katherine Young, BS, MEng; et al.
Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1453-1454. doi:10.1001/jamadermatol.2022.3872

This cross-sectional study assesses the validity of using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) code for melasma appended to a clinic visit to identify adult patients meeting diagnostic criteria for melasma.

Observation

Anakinra-Associated Amyloidosis

Sara Alehashemi, MD, MPH; Surendra Dasari, PhD; Adriana A. de Jesus, MD, PhD; et al.
Abstract Full Text
JAMA Dermatol. 2022;158(12):1454-1457. doi:10.1001/jamadermatol.2022.2124

This case report describes 2 patients with iatrogenic amyloidosis secondary to subcutaneous injections of anakinra to manage neonatal-onset multisystem inflammatory disease.

Recognizing Minimal Cutaneous Involvement or Systemic Symptoms in Monkeypox

Rachel Eisenstadt, MD; Walter J. Liszewski, MD; Cuong V. Nguyen, MD
Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1457-1458. doi:10.1001/jamadermatol.2022.4652

This case report describes 2 umbilicated and ulcerated, skin-colored papules on the genitals, as well as a honey-colored crusted papule on the face.

Comment & Response

SOX18 Targeting as a Potential, Viable Therapeutic Avenue for Kaposi Sarcoma

Päivi M. Ojala, PhD; Mathias Francoís, PhD
Abstract Full Text
JAMA Dermatol. 2022;158(12):1458-1459. doi:10.1001/jamadermatol.2022.4341

SOX18 Targeting as a Potential, Viable Therapeutic Avenue for Kaposi Sarcoma鈥擱eply

Rafael Salido-Vallejo, MD, PhD; Agustín España, MD, PhD
Abstract Full Text
JAMA Dermatol. 2022;158(12):1459-1460. doi:10.1001/jamadermatol.2022.4332

Geographic Distribution and Workforce Diversity of Dermatology Physician Assistants

Peter A. Young, MPAS; Cynthia F. Griffith, MPAS; Rebecca Vasquez, MD
Abstract Full Text
JAMA Dermatol. 2022;158(12):1460. doi:10.1001/jamadermatol.2022.4453

Geographic Distribution and Workforce Diversity of Dermatology Physician Assistants鈥擱eply

Justin D. Arnold, MD, MMSc; Andrzej Kozikowski, PhD
Abstract Full Text
JAMA Dermatol. 2022;158(12):1460-1461. doi:10.1001/jamadermatol.2022.4446
Correction

Errors in Figure 2

Abstract Full Text
free access
JAMA Dermatol. 2022;158(12):1461. doi:10.1001/jamadermatol.2022.5056
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
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JAMA Dermatol. 2022;158(12):1351. doi:10.1001/jamadermatol.2021.4239
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