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The EMBARK-HFpEF multicenter, open-label trial examines the effects of cardiac myosin inhibition with mavacamten in patients with heart failure with preserved ejection fraction with a left ventricular ejection fraction of 60% or greater.

This prespecified analysis of the Finerenone Trial to Investigate the Efficacy and Safety Superior to Placebo in Patients With Heart Failure (FINEARTS-HF) randomized clinical trial investigates the long-term effects of treatment with the nonsteroidal mineralocorticoid receptor antagonist, finerenone, in patients with heart failure with mildly reduced or preserved ejection fraction.

This cohort study investigates associations between a composite score for guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction at the time of discharge and clinical outcomes and costs.

This randomized clinical trial investigates if adding additional lesions next to the index effective ablation site will improve the ablation outcomes of outflow tract premature ventricular contractions (PVCs).

This cohort study evaluates the association of late gadolinium enhancement with sudden cardiac death or relevant associated events among patients younger than 21 years with hypertrophic cardiomyopathy.

This essay describes the author’s experience when her father had cardiac arrest.

This mendelian randomization study investigates the association between genetic risk for cardiovascular disease and immune-mediated diseases.

This cohort study evaluates the use of a machine learning model to adapt guideline recommendations to local populations.

The SAHELI randomized clinical trial among South Asian adults compares the effectiveness of a culturally adapted, group-based counseling intervention with written health education materials for reducing cardiovascular disease risk factors.

This substudy of the SEQUOIA-HCM (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy) randomized clinical trial investigates if treatment with aficamten improves exercise response beyond peak oxygen uptake measured by cardiopulmonary exercise testing in obstructive hypertrophic cardiomyopathy.

This genome-wide association study evaluates the genetics of atrioventricular pathways.

This case report describes a diagnosis of left ventricular anterior free-wall rupture in a patient given anticoagulant treatment for subacute myocardial infarction.

This post hoc analysis of a randomized clinical trial analyzes imaging data for atheroma volume at the lesion level from patients who received intensive lipid-lowering therapy with alirocumab plus statin compared with a statin alone.

This essay describes concerns that use of artificial intelligence (AI) as a replacement rather than a supplement in the provision of medical care may lead to loss of the art of medicine and the collaborative partnership between physician and patient.