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October 2024, Vol 10, No. 10, Pages 1309-1447

Original Investigation

Suicide Attempt and Suicide Death Among Spouses of Patients With Cancer

Abstract Full Text
JAMA Oncol. 2024;10(10):1323-1330. doi:10.1001/jamaoncol.2024.3036

This cohort study evaluates the risk of suicide attempt and suicide death among spouses of patients with a cancer diagnosis in Denmark.

Neoadjuvant Immune Checkpoint Inhibitors Plus Chemotherapy in Early Breast Cancer: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. 2024;10(10):1331-1341. doi:10.1001/jamaoncol.2024.3456

This meta-analysis examines the efficacy outcomes and safety profile of immune checkpoint inhibitors in combination with adjuvant chemotherapy in patients with early breast cancer across molecular phenotypes.

Lazertinib in EGFR-Variant Non–Small Cell Lung Cancer With CNS Failure to Prior EGFR Tyrosine Kinase Inhibitors: A Nonrandomized Controlled Trial

Abstract Full Text
open access
JAMA Oncol. 2024;10(10):1342-1351. doi:10.1001/jamaoncol.2024.2640

This nonrandomized controlled trial investigates central nervous system (CNS) activity with lazertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk

Abstract Full Text
JAMA Oncol. 2024;10(10):1354-1361. doi:10.1001/jamaoncol.2024.2503

This cohort study examines the use of regular aspirin use as a preventive intervention in individuals with varying risk factors for colorectal cancer.

Graded Organ Response and Progression Criteria for Kidney Immunoglobulin Light Chain Amyloidosis

Abstract Full Text
JAMA Oncol. 2024;10(10):1362-1369. doi:10.1001/jamaoncol.2024.2629

This cohort study examines graded kidney response criteria and their association with kidney and overall survival for patients with kidney light chain amyloidosis.

Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction: A Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(10):1370-1378. doi:10.1001/jamaoncol.2024.2652

This randomized clinical trial compares the outcomes of hypofractionation vs conventional fractionation postmastectomy radiation therapy regimens in patients undergoing implant-based breast reconstruction.

Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer

Abstract Full Text
JAMA Oncol. 2024;10(10):1379-1389. doi:10.1001/jamaoncol.2024.3044

This prospective-retrospective translational study of patients enrolled in SOFT assesses the predictive and prognostic performance of the Breast Cancer Index for ovarian function suppression benefit in premenopausal women with hormone receptor–positive breast cancer.

Immune Checkpoint Inhibitor–Induced Cardiotoxicity: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. 2024;10(10):1390-1399. doi:10.1001/jamaoncol.2024.3065

This systematic review and meta-analysis updates data on the incidence of cardiovascular adverse events in clinical trials of immune checkpoint inhibitors alone and in combination therapies and provides recommendations for management among patients treated for cancer.

Olaparib Without Androgen Deprivation for High-Risk Biochemically Recurrent Prostate Cancer Following Prostatectomy: A Nonrandomized Controlled Trial

Abstract Full Text
JAMA Oncol. 2024;10(10):1400-1408. doi:10.1001/jamaoncol.2024.3074

This nonrandomized controlled trial aims to determine the activity of olaparib monotherapy among patients with high-risk biochemically recurrent prostate cancer after radical prostatectomy.

Identification of Immune Checkpoint Inhibitor–Induced Diabetes

Abstract Full Text
has audio
JAMA Oncol. 2024;10(10):1409-1416. doi:10.1001/jamaoncol.2024.3104

This cohort study examines the incidence, risk factors, and clinical spectrum of immune checkpoint inhibitor–induced diabetes.

Review

Contemporary Management of Acute Myeloid Leukemia: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(10):1417-1425. doi:10.1001/jamaoncol.2024.2662

This review discusses advances in evidence-based treatment of acute myeloid leukemia with molecularly targeted drug therapy.

Externally Controlled Studies Using Real-World Data in Patients With Hematological Cancers: A Systematic Review

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(10):1426-1436. doi:10.1001/jamaoncol.2024.3466

This systematic review addresses the question of whether and to what extent the methods of real-world data studies compare to standard methods used in randomized clinical trials.

JAMA Oncology Clinical Challenge

An Anal Lesion in a 27-Year-Old Patient

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(10):1437-1438. doi:10.1001/jamaoncol.2024.3411

A 27-year-old male patient presented with anal discomfort and pruritus for 3 months. What is your diagnosis?

Viewpoint

Hormone Deprivation–Free Survival—Inequities Persist in Research Priorities for Patients With Cancer

Abstract Full Text
JAMA Oncol. 2024;10(10):1309-1310. doi:10.1001/jamaoncol.2024.2142

This Viewpoint discusses the importance of hormone deprivation–free survival as an end point for both men with prostate cancer and women with breast cancer.

When Best Care Takes a Back Seat to the Bottom Line

Abstract Full Text
JAMA Oncol. 2024;10(10):1311-1312. doi:10.1001/jamaoncol.2024.2485

This Viewpoint discusses the clinical vs economic success of magnetic resonance imaging combined with linear accelerator technology and its impact on patients.

MRI-Linac–Based Radiotherapy—Promising or Hype?

Abstract Full Text
JAMA Oncol. 2024;10(10):1313-1314. doi:10.1001/jamaoncol.2024.2488

This Viewpoint discusses the value of magnetic resonance imaging with linear accelerator (MRI-linac) technology, given the unmet needs in its development.

Editorial

Hidden Morbidity in Cancer Care—Mental Health in Spouses

Abstract Full Text
JAMA Oncol. 2024;10(10):1317-1318. doi:10.1001/jamaoncol.2024.2903

Neoadjuvant Immunotherapy—From Trials to Practice

Abstract Full Text
JAMA Oncol. 2024;10(10):1319-1321. doi:10.1001/jamaoncol.2024.2924
Invited Commentary

The Role of Lazertinib in Patients With EGFR-Variant Non–Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. 2024;10(10):1352-1353. doi:10.1001/jamaoncol.2024.2607
JAMA Oncology Patient Page

Caring for Your Heart During Cancer Treatment

Abstract Full Text
free access
JAMA Oncol. 2024;10(10):1447. doi:10.1001/jamaoncol.2024.3033

This JAMA Oncology Patient Page describes cardio-oncology, a relatively new area in medicine that focuses on taking care of the heart while going through cancer treatments.

Cancer Care Chronicles

Cold Capping—A Medical Student’s Perspective As a Caregiver

Abstract Full Text
JAMA Oncol. 2024;10(10):1315-1316. doi:10.1001/jamaoncol.2024.2637

This essay describes a medical student’s experience caring for her sister with breast cancer.

Poetry and Oncology

Crossing Over

Abstract Full Text
JAMA Oncol. 2024;10(10):1446. doi:10.1001/jamaoncol.2024.2670
Comment & Response

Hypofractionated Postprostatectomy Radiotherapy—Less is Really More?

Abstract Full Text
JAMA Oncol. 2024;10(10):1439. doi:10.1001/jamaoncol.2024.3131

Relapse Patterns in Early-Stage Endometrial Cancer Based on Molecular Classification

Abstract Full Text
JAMA Oncol. 2024;10(10):1439-1440. doi:10.1001/jamaoncol.2024.3239

Relapse Patterns in Early-Stage Endometrial Cancer Based on Molecular Classification—Reply

Abstract Full Text
JAMA Oncol. 2024;10(10):1440. doi:10.1001/jamaoncol.2024.3242

Inclusion of American Indian, Alaska Native, Native Hawaiian, and Pacific Islander Patients in Clinical Trial Travel Time

Abstract Full Text
JAMA Oncol. 2024;10(10):1440-1441. doi:10.1001/jamaoncol.2024.3405

Inclusion of American Indian, Alaska Native, Native Hawaiian, and Pacific Islander Patients in Clinical Trial Travel Time—Reply

Abstract Full Text
JAMA Oncol. 2024;10(10):1441-1442. doi:10.1001/jamaoncol.2024.3408

Unplanned Hospitalization Prediction During Chemoradiotherapy Via Machine Learning Classifiers

Abstract Full Text
JAMA Oncol. 2024;10(10):1442. doi:10.1001/jamaoncol.2024.3620

Unplanned Hospitalization Prediction During Chemoradiotherapy Via Machine Learning Classifiers—Reply

Abstract Full Text
JAMA Oncol. 2024;10(10):1442-1443. doi:10.1001/jamaoncol.2024.3623
Correction

Error in Abstract and Methods

Abstract Full Text
free access
JAMA Oncol. 2024;10(10):1443. doi:10.1001/jamaoncol.2022.0062

Error in Byline

Abstract Full Text
free access
JAMA Oncol. 2024;10(10):1443. doi:10.1001/jamaoncol.2024.4287
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2024;10(10):No Pagination Specified. doi:10.1001/jamaoncol.2023.4664
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