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September 2024 - January 1920

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June 2020, Vol 156, No. 6, Pages 613-716

Viewpoint

Chronic Pain in Hidradenitis Suppurativa Explained Through the Process of Central Sensitization

Kelsey R. van Straalen, MD
Abstract Full Text
JAMA Dermatol. 2020;156(6):615-616. doi:10.1001/jamadermatol.2020.0225

This Viewpoint discusses the current understanding about the mechanisms by which inflammation may modify pain perception via central sensitization in hidradenitis suppurativa and stresses the importance of future research into pain perception and management in these patients.

Editorial

An Evidence-Based Approach to Starting a Psychodermatology Clinic

Michelle Magid, MD, MBA; Jason S. Reichenberg, MD, MBA
Abstract Full Text
JAMA Dermatol. 2020;156(6):617-618. doi:10.1001/jamadermatol.2020.0393

A New Class of Topical Acne Treatment Addressing the Hormonal Pathogenesis of Acne

John S. Barbieri, MD, MBA
Abstract Full Text
JAMA Dermatol. 2020;156(6):619-620. doi:10.1001/jamadermatol.2020.0464
Original Investigation

Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne: Two Phase 3 Randomized Clinical Trials

Adelaide Hebert, MD; Diane Thiboutot, MD; Linda Stein Gold, MD; et al.
Abstract Full Text
open access
JAMA Dermatol. 2020;156(6):621-630. doi:10.1001/jamadermatol.2020.0465

This review of 2 randomized clinical trials assesses the safety and efficacy of topical clascoterone cream, 1%, a novel androgen receptor inhibitor for acne treatment.

Risk Factors for Keratinocyte Carcinoma in Recipients of Allogeneic Hematopoietic Cell Transplants

Jeffrey F. Scott, MD; Kevin R. Brough, MD; Konstantin V. Grigoryan, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):631-639. doi:10.1001/jamadermatol.2020.0559

This cohort study identifies and validates independent transplant- and host-associated risk factors for keratinocyte carcinoma among patients undergoing allogeneic hematopoietic cell transplant.

Incidence of and Factors Associated With Leprosy Among Household Contacts of Patients With Leprosy in Brazil

Camila Silveira Silva Teixeira, MsC; Júlia Moreira Pescarini, PhD; Flávia Jôse Oliveira Alves, MsC; et al.
Abstract Full Text
open access
JAMA Dermatol. 2020;156(6):640-648. doi:10.1001/jamadermatol.2020.0653

This cohort study evaluates the incidence of leprosy among household contacts of patients with leprosy in Brazil and the factors associated with development of leprosy in these contacts.

Efficacy and Safety of Continuous Risankizumab Therapy vs Treatment Withdrawal in Patients With Moderate to Severe Plaque Psoriasis: A Phase 3 Randomized Clinical Trial

Andrew Blauvelt, MD, MBA; Craig L. Leonardi, MD; Melinda Gooderham, MD; et al.
Abstract Full Text
open access
JAMA Dermatol. 2020;156(6):649-658. doi:10.1001/jamadermatol.2020.0723

This randomized clinical trial evaluates the safety and efficacy of risankizumab use for 2 years in patients with moderate to severe plaque psoriasis.

Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis: A Systematic Review and Network Meta-analysis

Aaron M. Drucker, MD; Alexandra G. Ellis, PhD; Michal Bohdanowicz, MD; et al.
Abstract Full Text
open access
JAMA Dermatol. 2020;156(6):659-667. doi:10.1001/jamadermatol.2020.0796

This systematic review and network meta-analysis compares the effectiveness and safety of systemic immunomodulatory treatments for adult patients with atopic dermatitis.

Evaluation of Ixekizumab Treatment for Patients With Pityriasis Rubra Pilaris: A Single-Arm Trial

Dylan Haynes, MD; Jennifer L. Strunck, BS; Christina A. Topham, BS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):668-675. doi:10.1001/jamadermatol.2020.0932

This single-arm nonrandomized clinical trial assesses the clinical response and safety of ixekizumab treatment in adults with moderate to severe pityriasis rubra pilaris.

Brief Report

An Intrapatient Concordance Study of Mismatch Repair Protein Immunohistochemical Staining Patterns in Patients With Muir-Torre Syndrome

Cuong V. Nguyen, MD; Kevin J. Gaddis, MD; Michael R. Stephens, MD; et al.
Abstract Full Text
JAMA Dermatol. 2020;156(6):676-680. doi:10.1001/jamadermatol.2020.0433

This case series assesses the concordance of mismatch repair protein immunohistochemical staining between different sebaceous neoplasms in patients with Muir-Torre syndrome.

Evaluation of Hidradenitis Suppurativa Disease Course During Pregnancy and Postpartum

Alexis B. Lyons, MD; Anjelica Peacock, MD; Shanice A. McKenzie, BS; et al.
Abstract Full Text
JAMA Dermatol. 2020;156(6):681-685. doi:10.1001/jamadermatol.2020.0777

This cohort study examines changes in the disease course of hidradenitis suppurativa during pregnancy and postpartum.

Review

Multidisciplinary and Holistic Models of Care for Patients With Dermatologic Disease and Psychosocial Comorbidity: A Systematic Review

Arsh Patel, MS; Mohammad Jafferany, MD
Abstract Full Text
JAMA Dermatol. 2020;156(6):686-694. doi:10.1001/jamadermatol.2020.0394

This systematic review performs an in-depth analysis of available literature, highlights the importance and benefits of providing multidisciplinary care, and provides structural evidence of existing liaison clinics for more widespread future application among patients with psychocutaneous disease.

Images in Dermatology

Acral Purpura in Dermatitis Herpetiformis

Alejandro García-Vázquez, MD; Santiago Guillen-Climent, MD; María Isabel Pinazo-Canales, MD
Abstract Full Text
JAMA Dermatol. 2020;156(6):695. doi:10.1001/jamadermatol.2020.0378

This case report describes a 32-year-old woman with pruritic, small vesicles and papules on the eyelids, elbows, knees, buttocks, and scalp, as well as reddish-brown hemorrhagic lesions on the palms, soles, and volar surface of the fingers.

Necrobiotic Xanthogranuloma

Gerson Dellatorre, MD; Jerusa Karina Miqueloto, MD
Abstract Full Text
JAMA Dermatol. 2020;156(6):696. doi:10.1001/jamadermatol.2020.0897

This case report describes a woman in her 40s who presented with asymptomatic yellow plaques on her eyelids and similar ulcerated plaques on her trunk and limbs.

JAMA Dermatology Clinicopathological Challenge

A Patient With a 10-Year History of Generalized Pruritus

Julian Boix-Vilanova, MD; Anabel Ballester, MD; Juan Garcias-Ladaria, MD
Abstract Full Text
JAMA Dermatol. 2020;156(6):697-698. doi:10.1001/jamadermatol.2020.0886

A woman in her early 40s presented with generalized pruritus, erythematous papules, some of them crusted, and some excoriations located over the trunk and upper extremities. What is your diagnosis?

JAMA Dermatology Patient Page

What Is Mohs Surgery?

Jeremy R. Etzkorn, MD, MS; Murad Alam, MD, MSCI, MBA
Abstract Full Text
free access has multimedia has audio
JAMA Dermatol. 2020;156(6):716. doi:10.1001/jamadermatol.2020.0039

This JAMA Patient Page describes Mohs surgery and explains why it is highly effective at removing skin cancer.

  • Video: What is Mohs Surgery?
  • Audio: USPSTF Recommendation: Screening for Skin Cancer
Research Letter

Association of Inflammation With Progression of Hair Loss in Women With Frontal Fibrosing Alopecia

David Saceda-Corralo, MD, PhD; Cristina Pindado-Ortega, MD; Oscar M. Moreno-Arrones, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):700-702. doi:10.1001/jamadermatol.2020.0359

This cohort study assesses the association of inflammatory symptoms with the progression of hair loss in women with frontal fibrosing alopecia.

Assessment of Outcomes With Pulsed Dye Laser Treatment of Port-Wine Stains Located Proximally vs Distally on Extremities

Wenxin Yu, MD, PhD; Jiafang Zhu, MD; Yue Han, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):702-704. doi:10.1001/jamadermatol.2020.0363

This nonrandomized clinical trial evaluates the morphological and anatomical features of port-wine stains treated by pulsed dye laser to assess differences in treatment efficacy based on proximal vs distal location on extremities.

Evaluation of Cyclosporine for the Treatment of DRESS Syndrome

Emily Nguyen, BS; Daniel Yanes, MD; Sotonye Imadojemu, MD, MBE; et al.
Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):704-706. doi:10.1001/jamadermatol.2020.0048

This retrospective case-control study of 26 adults evaluates the use of cyclosporine A in the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) compared with standard systemic glucocorticosteroids.

Observation

Treatment of Trametinib-Associated Folliculitis Eruption With Fluconazole

Chelsea Steele, MPH; Timothy Gershon, MD, PhD; Craig Burkhart, MD; et al.
Abstract Full Text
JAMA Dermatol. 2020;156(6):706-708. doi:10.1001/jamadermatol.2020.0284

This case report describes 5 patients with neurofibromatosis type 1 who developed folliculitis eruptions following treatment with trametinib.

Pembrolizumab for Treatment of a Patient With Multiple Cutaneous Squamous Cell Carcinomas and Recessive Dystrophic Epidermolysis Bullosa

Alfredo Piccerillo, MD; Maya El Hachem, MD; Rita De Vito, MD; et al.
Abstract Full Text
JAMA Dermatol. 2020;156(6):708-710. doi:10.1001/jamadermatol.2020.0304

This case report describes a woman in her 40s with recessive dystrophic epidermolysis bullosa and multiple cutaneous squamous cell carcinomas who was successfully treated with pembrolizumab.

JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2020;156(6):613. doi:10.1001/jamadermatol.2019.3020
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